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|Season||Yes! Pretty Cure 5|
|Japanese Voice Actor||Kazuko Sugiyama|
Desperaia (デスパライア Desuparaia) The top of the Nightmares. She intends to gain eternal life to bring despair to all the world, and has ordered her subordinates to obtain the Dream Collet. She has long brown hair and wears a purple dress and a mask.
Desperaia is not very active until about the middle of the series. In fact it seems that Bunbee is in charge of Nightmare for the first couple of episodes. She's usually seen behind her desk wearing a mask and giving orders to her male secretary Kawarino. Before this she presumably ordered the attack on the Palimier kingdom to get the Dream Collette because of her selfish desire to be young and immortal forever. She continues this quest through Kawarino and has the Pretty cures attacked at every turn. She makes a short apprentice mid-series by leaving he desk to confront the cures. In the last three episodes she takes a sightly more active role by helping Kawarino and is totally surprised by the hope that Yumehara Nozomi and her friends have despite the fact that the Dream Colette has already been used up.
For most of the series she looks like a Japanese masked doll and wears traditional clothing and headdresses.
Her name "Desperaia" appears to play of the words "despair" and "pariah".
- Desperia is the first main villain to be female.
- Desperia is the first main villain to form a truce instead of continuing with their original plan.
- Her and the other main villains' silhouette (Dark King, Goyan, the Boss, Moebius and Dune) are seen in Pretty Cure All Stars DX 3: Mirai ni Todoke! Sekai wo Tsunagu☆Niji-Iro no Hana. Desperaia's silhouette represents Nightmare.